Application of Microcrystalline Cellulose Powders Obtained from Gossypiumherbaceum As Dry Binder in the Formulation of Diazepam Tablets

Background: Microcrystalline cellulose (MCC) is a popular dry binder in tablet formulation. Differences its processing methods can significantly affect tableting properties. Aim: Assessment of the and in-vitro release properties diazepam tablets formulated with Gossypiumherbaceum (GH) derived MCC that was dried by two different methods. Methods: G.herbaceum bolls were de-lignified sodium hydroxide solutions to obtain α-cellulose which hydrolyzed 2.0 N hydrochloric acid MCC. The neutralized damp separated into portions. One portion fluid bed (MCC-GossF) while other lyophilized (MCC-GossL). Diazepam prepared 20, 30 40%w/w MCC-GossF MCC-GossL..Avicel PH 102 (AVH-102) served as comparing standard. formulations evaluated using standard Results: powders flowed well met British Pharmacopoiea specifications. containing MCC-GossL (DGL) stronger than those (DCF) (p<0.05). disintegration times < 2 min friability ≤ 1%. strength AVH-102 (DAV) compared DGL tablets. More 80% released from Conclusion: GH MCCs good binders formulation